The four-alarm blaze broke out on the second floor of the 2½-story wood-frame home next to the St. Nicholas church and school on President Street shortly before 1 p.m. Tuesday, March 22, responders said.
Power lines came down on one of the responding fire trucks, prompting an urgent request for a PSE&G crew, they said.
The injuries to the two firefighters weren't considered life-threatening, according to responders at the scene. One involved a knee injury, they said.
Firefighters were pulled from the building less than a half-hour after they arrived as flames shot out of the eaves.
They continued to battle the blaze from the exterior.
Click here to follow Daily Voice Middletown and receive free news updates.